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These changes to your complexion are beautiful and natural.

Cosmetic bottles and tubes overlapping on a pink background.

Source images: Courtesy of brands; Collage: Laneen Wells

Read on for the 12 best serums for mature skin the web has to offer.

Meet SkinMedica’s TNS Advanced+ Serum, a Best of Beauty winner.

The same goes forMorgan Rabach, MD, a board-certified dermatologist in New York City.

SkinMedica TNS Advanced+ Serum in white and silver bottle on light grey background

Plus, ferulic acid gives vitamins C and E a rejuvenating boost, further amplifying their benefits.

It also works well to soothe irritation from in-office treatments, sun damage, and beyond.

In an editor’s words?

SkinCeuticals C E Ferulic in clear amber bottle with black pipette on light gray background

It has “very high-quality results and packaging,” says senior audience development directorLexi Herrick.

“I love the roller software: It comes out quickly, evenly, and dries down fast.”

Also, shout out to the natural powers of free radical-neutralizing licorice.

Alastin HA Immerse Serum in metallic silver bottle on light gray background

Then, polyglutamic acid offers four times the amount of hyaluronic acid, intensifying the formula’s pumping ability.

And, a friendly reminder: always wearsunscreen with SPF 30or higher when using retinol during the day.

Its cosmetically elegant, too, she says.

Paula’s Choice Intensive Wrinkle-Repair Retinol Serum gray bottle with white pump cap on light gray background

What ingredients should I look for in a serum for mature skin?

New York City-based board-certified dermatologistMichele Green, MD, vouches for chemical exfoliants in the form ofalphaandbeta hydroxy acids.

“Salicylic, glycolic, and lactic acids help exfoliate the outermost layer of cells,” Dr. GreentoldAllure.

Isdin Melatonik Overnight Serum in black bottle with pipette

We review ingredients, scrutinize brand claims, and, when necessary, examine peer-reviewed scientific and medical studies.

To learn more information on our reporting and testing processes, read our completereviews process and methodology page.

Our staff and testers

A beauty product is a personal purchase.

Kate Somerville KateCeuticals SuperCell Rejuvenation Serum in silver branded tube component with silver cap and black accents on a light gray background

Mature skin deserves extra love, a.k.a.

Dr. Dennis Gross Skincare Vitamin C Lactic 15% Firm & Bright Serum orange dropper with red best of beauty seal on light grey background

Charlotte Tilbury Magic Serum Crystal Elixir

Beauty Pie Youthbomb Double Retinol Action Skin Overhaul Serum in copper bottle with metallic cap

Vichy Neovadiol Meno 5 Serum in clear bottle

RoC Derm Correxion Fill + Treat Serum in silver packaging

Avene Cicalfate+ Intensive Skin Restorative Serum glass tincture on gray background