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Skin-care products arent known for instant gratification, but using the best wrinkle cream proves the power of patience.

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Photographed by CARLOS and ALYSE. Stylist: Fiona Green. Hair: Jenni Iva Wimmerstedt. Makeup: Andrew Colvin. Manicure: Elina Ogawa. Model: Brandi Quinones. Shirt by Issey Miyake. Earrings by Paula Mendoza.

We tapped dermatologists to learn whichwrinkle serumsand creams actually workhere are the best 16.

Our Top Picks

Frequently Asked Questions

Best Wrinkle Cream Overall:SkinCeuticals A.G.E.

Interrupter Advanced

SkinCeuticals

A.G.E.

SkinCeuticals A.G.E. Interrupter Advanced on light gray background

Interrupter Advanced

Dermstore

Bluemercury

Why we love it:SkinCeuticalss A.G.E.

Interrupter Advanced isnt messing around.

Youll start to see results like increased firmness, reduced crepiness, and brighter complexion at around 12 weeks.

Neocutis BioSerum Firm in neon blue bottle

Our editors have experienced the goodness for themselves.

Many moisturizers sting my dry, sensitive skinbut not the A.G.E.

Interrupter Advanced, senior editor Jesa Marie Calaor previouslytoldAllure.

Beauty Pie Youthbomb Breakthrough Repair Cream on light gray background

It coddles my skin, comforting the extra-dry patches and leaving my complexion bouncy and bright.

The formula combines growth factors andpeptidesfor softer-looking fine lines and wrinkles, she says.

Thegrowth factorsare derived from cultured cellsno actual human tissue is involved.

Isdin Isdinceuticals Age Contour Night Face Moisturizer in black jar with gold lid

The brand says youll start seeing a difference in six days to keep antsiness at a minimum.

If you prefer a richer formula or havereallydry skin, considerNeocutis’s BioCream Firme Riche.

“When wet, the sponge expands to occupy more space, giving aplumping effect,” she says.

Alastin Restorative Skin Complex in clear bottle with silver cap on light gray background

This lightweight formula is especially helpful for those looking to target dullness and discoloration since it includes brighteners likeniacinamideandsqualane.

We love how thoroughly this formula hydrates, all while going easy on sensitive skin.

“Vitamin Esteps in to support a strong skin barrier, and as a result, minimize moisture loss.

Dr. Dennis Gross Advanced Retinol + Ferulic Intense Wrinkle Cream in rich brown jar

The formula also uses green pea-derived peptides to boost collagen and elastin production over time.

The result is the firming, hydrating, and line-softening benefits youve been searching for.

As for those wrinkles?

Irene Forte Prickly Pear Face Cream in gray bottle with white cap

Plus, a little goes a long way.

The combination keeps skin calm yet firm.

it’s possible for you to (and should!)

Revision Skincare Revox 7 black pump bottle on light gray background

extend this down to your neck and chest to max out benefits.

Oh, and did we mention that this cream has taken home five Best of Beauty Awards?

When will I start seeing results from wrinkle creams?

A light pink tub of Caudalie Resveratrol Lift Firming Night Cream on light gray background

You won’t see results from any skin product overnight, so your expectations have to be realistic.

In other words, patience is a virtue.

And, the earlier you start using wrinkle cream, the better.

CosMedix Peptide-Rich Defense Moisturizer SPF 50 blue chrome bottle with white pump cap on light gray background

What in-office treatments target wrinkles?

These can promote collagen production on a deeper level than the treatment alone.

We review ingredients, scrutinize brand claims, and, when necessary, examine peer-reviewed scientific and medical studies.

EltaMD PM Therapy Facial Moisturizer in white bottle with white pump

To learn more information on our reporting and testing processes, read our completereviews process and methodology page.

Our staff and testers

A beauty product is a personal purchase.

Can we honestly deem a high-end diffuser worthy of your hard-earned cash if its never been tested on curls?

SkinMedica HA5 Rejuvenating Hydrator in silver bottle with silver cap

Aging skin is beautiful skinand these nourishing treatments keep it in tip-top shape:

Done reading?

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Shop all of our latest obsessionsin one place!

Clarins Double Serum amber serum bottle with gold pump top and clear cap on light gray background

Olay Regenerist Micro-Sculpting Cream in red jar with silver lid

Clinique Smart Clinical Repair Wrinkle Correcting Cream in purple jar with silver lid

RoC Retinol Correxion Deep Wrinkle Night Cream white and gold tube on light gray background